Genre
- Journal Article
As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
United States
American Society For Microbiology : Washington Dc
Accession Number: 19297495. Language: English. Language Code: eng. Date Revised: 20100922. Date Created: 20090513. Date Completed: 20090529. Update Code: 20111122. Publication Type: Journal Article; Research Support, Non-U.S. Gov't. Journal ID: 0113724. Publication Model: Print-Electronic. Cited Medium: Internet. NLM ISO Abbr: J. Virol. PubMed Central ID: PMC2681948. Cites: J Gen Virol. 1997 Jun;78 ( Pt 6):1379-83. (PMID: 9191933). Cites: EMBO J. 1997 May 1;16(9):2482-92. (PMID: 9171361). Cites: J Mol Biol. 1987 Aug 20;196(4):947-50. (PMID: 3681984). Cites: J Mol Biol. 1982 May 5;157(1):105-32. (PMID: 7108955). Cites: J Virol. 2004 Sep;78(18):9904-17. (PMID: 15331724). Cites: J Virol. 2004 Apr;78(8):4342-51. (PMID: 15047847). Cites: Virus Res. 2004 Apr;101(1):15-28. (PMID: 15010214). Cites: J Virol. 2004 Mar;78(6):2808-18. (PMID: 14990700). Cites: J Virol. 2003 Sep;77(18):9769-79. (PMID: 12941885). Cites: Gene. 2002 Oct 16;299(1-2):1-34. (PMID: 12459250). Cites: J Gen Virol. 2002 Aug;83(Pt 8):1941-51. (PMID: 12124458). Cites: J Virol. 2002 Mar;76(5):2131-40. (PMID: 11836390). Cites: J Virol. 2002 Jan;76(2):609-18. (PMID: 11752152). Cites: J Virol. 2000 Jul;74(14):6546-55. (PMID: 10864668). Cites: Comp Med. 2000 Apr;50(2):199-205. (PMID: 10857011). Cites: EMBO J. 2000 Mar 1;19(5):902-12. (PMID: 10698932). Cites: Virology. 2000 Mar 30;269(1):212-24. (PMID: 10725213). Cites: J Virol. 2009 Jan;83(2):552-61. (PMID: 18971262). Cites: Vet Microbiol. 2009 Jan 1;133(1-2):34-42. (PMID: 18656318). Cites: PLoS Pathog. 2008 Mar;4(3):e1000016. (PMID: 18369467). Cites: Virology. 2008 Apr 10;373(2):310-21. (PMID: 18191982). Cites: Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11424-9. (PMID: 17592121). Cites: Virus Res. 2007 Feb;123(2):105-19. (PMID: 17018239). Cites: J Virol. 2005 Jul;79(13):8090-100. (PMID: 15956554). Cites: J Virol. 2005 May;79(10):6216-26. (PMID: 15858006). Cites: J Biol Chem. 2004 Dec 3;279(49):51386-94. (PMID: 15448165). Cites: Curr Top Microbiol Immunol. 2005;285:25-66. (PMID: 15609500). Cites: Virology. 1999 Aug 1;260(2):316-28. (PMID: 10417266). Cites: J Gen Virol. 1998 Oct;79 ( Pt 10):2481-9. (PMID: 9780055). Cites: Arch Virol. 1997;142(12):2547-52. (PMID: 9672614). Cites: Structure. 1996 Aug 15;4(8):957-67. (PMID: 8805574). Linking ISSN: 0022538X. Subset: IM. Date of Electronic Publication: 2009 Mar 18; ID: 19297495
Language
- English
Subjects
- Amino Acid Sequence
- Viral Proteins/genetics
- Membrane Proteins/*metabolism
- Membrane Proteins/classification
- Viral Proteins/chemistry
- Cell Line
- Open Reading Frames/genetics
- Membrane Proteins/chemistry
- Viral Proteins/classification
- Protein Biosynthesis/*genetics
- Membrane Proteins/genetics
- Genome, Viral/genetics
- Viral Proteins/*metabolism
- animals
- Cercopithecus aethiops
- Virus Internalization
- Giant Cells/*cytology
- Molecular Sequence Data
- Reoviridae/*metabolism
- Reoviridae/genetics
- Base Sequence
- Giant Cells/*metabolism
- Salmo salar/virology