Genre
- Journal Article
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily. A critical role for BMP signaling in the development of the metanephric kidney is supported by a growing number of studies using in vitro assays and in vivo animal models. Here we review current knowledge of BMPs, BMP receptors and regulators of the BMP signaling pathway in the developing kidney. We highlight major gaps in our knowledge of the roles of BMP signaling in the development of the normal and abnormal kidney and identify areas and techniques likely to improve our understanding.
Program in Developmental and Stem Cell Biology The Hospital for Sick Children, Toronto, ON, Canada.
England
Elsevier : London
Accession Number: 18331343. Language: English. Language Code: eng. Date Revised: 20091119. Date Created: 20080923. Date Completed: 20081217. Update Code: 20111122. Publication Type: Journal Article; Review. Journal ID: 0401650. Publication Model: Print-Electronic. Cited Medium: Internet. NLM ISO Abbr: Differentiation Linking ISSN: 03014681. Subset: IM. Date of Electronic Publication: 2008 Mar 07; ID: 18331343
Language
- English
Subjects
- Bone Morphogenetic Proteins/metabolism
- animals
- Humans
- Signal Transduction/genetics
- Bone Morphogenetic Proteins/*physiology
- Gene Expression Regulation, Developmental/physiology
- Signal Transduction/*physiology
- Bone Morphogenetic Proteins/biosynthesis
- Forecasting
- Kidney/*physiology
- Kidney/abnormalities
- Kidney/growth & development
- Bone Morphogenetic Proteins/genetics
- Kidney/*embryology
- Bone Morphogenetic Protein Receptors/physiology