Synthesis of B5ABMA using ring opening chemistry and poly(B5ABMA) via reversible addition fragmentation chain transfer polymerization

Many vitamin B5 derived analogues have been developed and shown to exhibit interesting properties such as antibacterial activity and antifouling capabilities. However, these small molecules have been seen in limited applications due to their instability under physiological conditions. Therefore, it is of interest to produce macromolecules of vitamin B5 derived analogues which could have more widespread applications. For this reason, polymers of vitamin B5 derived analogues are of interest. Polymers of vitamin B5 derived analogues has a vast number of potential applications, including biomedicines and pharmaceuticals. Herein, the synthesis of the vitamin B5 derived analogue, N-(4‐aminobutyl)methacrylamide hydrochloride (B5ABMA) via ring opening chemistry and the production of three different molecular weight polymers of B5ABMA by RAFT polymerization is described. To the best of our knowledge, there has been no previous publications regarding the synthesis of B5ABMA or poly(B5ABMA) and the analysis of their potential antibacterial and antifouling properties. The successful synthesis of this vitamin B5 derived analogue and its associated polymer now allow for future analysis of its potential antifouling, antibacterial, and hygroscopic properties, thereby determining its potential applications in pharmaceuticals and biomedicines.