Lo, J., and Robert A. R. Hurta. “Over-Expression of K-FGF or BFGF Results in Altered Expression of Matrix Metalloproteinases: Correlations With Malignant Progression and Cellular Invasion”. Cell Biology International, vol. 26, no. 4, 2002, pp. 319-25, https://doi.org/10.1006/cbir.2001.0858.

Genre

  • Journal Article
Contributors
Author: Lo, J.
Author: Hurta, Robert A. R.
Date Issued
2002
Abstract

Matrix metalloproteinase (MMP) expression was investigated in NIH-3T3 fibroblasts that secrete K-FGF and in NIH-3T3 cells which express chimeric bFGF with a signal sequence targeting bFGF to the secretory pathway. Correlations between altered MMPs' and other proteases' expression and malignant potential were determined. Correlations between the expression of MMPs and the invasion ability of K-FGF and bFGF over-expressing cells were also determined. The resulting correlation between alterations in proteases and malignant progression supports a model which suggests that growth factor modulation of protease expression is part of the altered growth regulatory program associated with cellular transformation and malignant progression. (C) 2002 Elsevier Science Ltd. All rights reserved.

Note

St Michaels Hosp, Dept Lab Med & Pathobiol, Toronto, ON M5B 1A6, Canada. Univ Toronto, Toronto, ON M5B 1A6, Canada. Univ Prince Edward Isl, Dept Biol, Charlottetown, PE C1A 4P3, Canada.; Hurta, RAR, St Michaels Hosp, Dept Lab Med & Pathobiol, To(TRUNCATED)

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Source type: Electronic(1)

Language

  • English

Subjects

  • malignant progression
  • amplification
  • TUMORS
  • ONCOGENE
  • bFGF
  • protease expression
  • HST
  • K-FGF
  • TRANSFORMATION
  • CELLS
  • INT-2
  • FIBROBLAST GROWTH-FACTOR
  • Cell Biology
Page range
319-325
Host Title
Cell Biology International
Host Abbreviated Title
Cell Biol.Int.
Volume
26
Issue
4
ISSN
1065-6995
DOI
https://doi.org/10.1006/cbir.2001.0858

Department