Genre
- Journal Article
Early lesions in these cultures (3-10 hours after virus inoculation) consisted of nucleolar sweating and disruption; there was loss of RNA from the nucleo-lus and segregation of nueleolar components (demonstrated by electron microscopy). During the middle phase (10-34 hours) three types of eosinophilic intranuclear inclusion appeared; the inclusions seemed to be formed by progressive transformations. Viral antigen was demonstrated in the nucleus by immuno-fluorescent staining, with viral replication observed at the same time by electron microscope. The late phase (34-72 hours) was manifested by cellular degeneration and viral release into the cytoplasm..
Dep. Vet. Path., State Univ., Columbus, Ohio 43210.
Source type: Electronic(1)
http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=&isbn=&volume=&issue=&spage=289&pages=289-308&date=1969&title=Pathologia%20vet&atitle=Effects%20of%20a%20pathogenic%20canine%20herpesvirus%20on%20established%20thyroid%20adenoearanoma%20cell%20cultures.&aulast=Johnson&pid=%3Cauthor%3EJohnson%2c%20G%20R%3bKoestner%2c%20A%3bKindig%2c%20O%3bShad%20duck%2c%20J%20A%3C%2Fauthor%3E%3CAN%3E19702201709%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3E
Language
- English
Subjects
- cytoplasm
- degeneration
- small mammals
- Antigens
- viruses
- animals
- carnivores
- viral diseases
- lesions
- secretion
- Canidae
- Host Resistance and Immunity
- Parasites Vectors Pathogens and Biogenic Diseases of Animals
- sweating
- viral replication
- STAINING
- Dogs
- Chordata
- Techniques and Methodology
- inoculation
- Animal Physiology and Biochemistry Excluding Nutrition
- Fissipeda
- Herpesviridae
- thyroid gland
- Eosinophils
- canine herpesvirus
- cell cultures
- RELEASE
- Animal Tissue and Cell Culture
- cultures
- mammals
- segregation
- Pets and Companion Animals
- vertebrates
- RNA
- Canis