Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1? in rats

Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1? can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone. The present experiment provides independent confirmation that intracerebroventricular administration of 10ng IL-1? in the rat can have a selective effect on the retrieval of trial unique information about the location of food on an eight-arm radial maze.