Genre
- Journal Article
Contributors
Author: Song, Cai
Author: Leonard, B. E.
Date Issued
1997
Abstract
The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel "open field" environment, male OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7.5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesion, which was reversed by desipramine administration. Results from serum crossover studies and enzyme assay showed that some factor in the serum of OB rats may suppress neutrophil phagocytosis.
Note
John Wiley & Sons
Language
- English
Subjects
- Neurotransmitters
- Immunology
- Amines
- Behavior Change
- Animal Models
- Rats
- Major Depression
- Desipramine
- Olfactory Bulb
- Brain Lesions
Page range
99-103
Host Title
Human Psychopharmacology: Clinical and Experimental
Host Abbreviated Title
Hum.Psychopharmacol.Clin.Exp.
Volume
12
Issue
2
ISSN
0885-6222
1099-1077