Genre
- Journal Article
Stability-indicative detn. of bambuterol hydrochloride (BH) in the presence of its degrdn. product (terbutaline), which is also the metabolite, is investigated. The degrdn. product was isolated, via acid-degrdn., characterized and elucidated. Selective quantification of BH, singly in bulk form, pharmaceutical formulations and/or in the presence of its major degrdn. product is demonstrated. The indication of stability was undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are second deriv. (2D), first deriv. of ratio spectra (1DD), ratio subtraction and bivariate anal. [on SciFinder(R)]
Faculty of Pharmacy, Department of Analytical Chemistry, Cairo University, Cairo, Egypt.
Copyright (C) 2012 American Chemical Society (ACS). All Rights Reserved.; Section Code: 64-3; CODEN: PGHLA5; CAS Registry Numbers: 81732-46-9 (Bambuterol hydrochloride) Role: ANT (Analyte), ANST (Analytical study) (selective detn. of bambuterol hydrochloride in presence of its active metabolite terbutaline by spectrophotometric methods); 23031-25-6 (Terbutaline) Role: ARU (Analytical role, unclassified), ANST (Analytical study) (selective detn. of bambuterol hydrochloride in presence of its active metabolite terbutaline by spectrophotometric methods)
Source type: Electronic(1)
http://pharmacie-globale.info/index.php?option=com_docman&task=doc_download&gid=167&Itemid=41
Language
- English
Subjects
- detn
- deriv
- Spectrophotometry (second-deriv.
- terbutaline
- Spectrophotometry (deriv., first deriv. of ratio spectra
- second
- hydrochloride
- bambuterol
- selective detn. of bambuterol hydrochloride in presence of its active metabolite terbutaline by spectrophotometric methods)
- STABILITY
- Stability (selective detn. of bambuterol hydrochloride in presence of its active metabolite terbutaline by spectrophotometric methods)
- Spectrophotometry