Genre
- Journal Article
The molecular signals that regulate growth and branching of the ureteric bud during formation of the renal collecting system are largely undefined. Members of the bone morphogenetic protein (BMP) family signal through the type I BMP receptor ALK3 to inhibit ureteric bud and collecting duct cell morphogenesis in vitro. We investigated the function of the BMP signaling pathway in vivo by generating a murine model of ALK3 deficiency restricted to the ureteric bud lineage (Alk3(UB-/-) mice). At the onset of branching morphogenesis, Alk3(UB-/-) kidneys are characterized by an abnormal primary (1 degrees ) ureteric bud branch pattern and an increased number of ureteric bud branches. However, during later stages of renal development, Alk3(UB-/-) kidneys have fewer ureteric bud branches and collecting ducts than wild-type kidneys. Postnatal Alk3(UB-/-) mice exhibit a dysplastic renal phenotype characterized by hypoplasia of the renal medulla, a decreased number of medullary collecting ducts, and abnormal expression of beta-catenin and c-MYC in medullary tubules. In summary, normal kidney development requires ALK3-dependent BMP signaling, which controls ureteric bud branching.
Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
United States
American Society of Nephrology : Washington, DC
Accession Number: 18178801. Language: English. Language Code: eng. Date Revised: 20120625. Date Created: 20080107. Date Completed: 20080305. Update Code: 20120625. Publication Type: Journal Article; Research Support, Non-U.S. Gov't. Journal ID: 9013836. Publication Model: Print. Cited Medium: Internet. NLM ISO Abbr: J. Am. Soc. Nephrol. PubMed Central ID: PMC2391036. Cites: Genesis. 2002 Feb;32(2):69-72. (PMID: 11857780). Cites: J Am Soc Nephrol. 2007 Apr;18(4):1121-9. (PMID: 17314325). Cites: Dev Biol. 2004 Feb 15;266(2):285-98. (PMID: 14738877). Cites: Endocrinology. 1995 Jun;136(6):2652-63. (PMID: 7750489). Cites: Nature. 1994 Jan 27;367(6461):380-3. (PMID: 8114940). Cites: Genes Dev. 1995 Dec 15;9(24):3027-37. (PMID: 8543149). Cites: Development. 1995 Dec;121(12):4057-65. (PMID: 8575306). Cites: Nature. 1996 Jul 4;382(6586):73-6. (PMID: 8657307). Cites: Genes Dev. 1996 Jul 1;10(13):1580-94. (PMID: 8682290). Cites: Development. 1997 Jan;124(1):113-23. (PMID: 9006072). Cites: Dev Dyn. 1997 Mar;208(3):349-62. (PMID: 9056639). Cites: Am J Physiol. 1997 Dec;273(6 Pt 2):F961-75. (PMID: 9435686). Cites: J Biol Chem. 1999 Sep 10;274(37):26305-14. (PMID: 10473586). Cites: Hum Mol Genet. 2000 Jan 1;9(1):1-11. (PMID: 10587573). Cites: J Cell Sci. 2000 Jan;113 Pt 2:269-78. (PMID: 10633078). Cites: J Clin Invest. 2000 Apr;105(7):863-73. (PMID: 10749566). Cites: Development. 2001 Dec;128(23):4747-56. (PMID: 11731455). Cites: J Am Soc Nephrol. 2003 Nov;14(11):2767-74. (PMID: 14569086). Cites: Development. 2003 Jul;130(14):3175-85. (PMID: 12783789). Cites: Development. 2004 Jul;131(14):3401-10. (PMID: 15201225). Cites: Development. 2005 Jan;132(1):215-25. (PMID: 15576399). Cites: Dev Biol. 2004 Dec 15;276(2):403-15. (PMID: 15581874). Cites: Kidney Int. 2005 Feb;67(2):420-31. (PMID: 15673289). Cites: Dev Cell. 2005 Feb;8(2):229-39. (PMID: 15691764). Cites: Mech Dev. 2005 Jul;122(7-8):928-38. (PMID: 15925496). Cites: Development. 2003 Jun;130(12):2753-66. (PMID: 12736218). Linking ISSN: 10466673. Subset: IM. Date of Electronic Publication: 20080101; ID: 18178801
Source type: Electronic(1)
http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=18178801&site=eds-live
Language
- English
Subjects
- animals
- Mice, Knockout
- Gene Deletion*
- Kidney Tubules, Collecting/*physiology
- Mice
- Mice, Transgenic
- Genes, Reporter
- Ureter/embryology
- Ureter/physiology
- Gene Expression Regulation, Developmental*
- Bone Morphogenetic Protein Receptors, Type I/*physiology
- Kidney/embryology
- Kidney Tubules, Collecting/embryology
- embryonic development
- Green Fluorescent Proteins/genetics