Bastlund, J. F., et al. “Reductions in Paradoxical Sleep Time in Adult Rats Treated Neonatally With Low Dose Domoic Acid”. Behavioural Brain Research, vol. 205, no. 2, 2009, pp. 564-7, https://doi.org/10.1016/j.bbr.2009.07.018.

Genre

  • Journal Article
Contributors
Author: Bastlund, J. F.
Author: Tasker, R. A.
Author: Gill, D. A.
Author: Anderson, N. J.
Date Issued
2009
Abstract

One hallmark of neurological dysfunction is a reduction in paradoxical sleep (PS) time. To determine if adult rats treated neonatally with low dose domoic acid have altered sleep patterns, a home cage analysis of electroencephalogram (EEG) waveforms was performed using radio telemetry. Domoate treated rats spent significantly less time in PS than controls during daytime hours even though they spent the same total amount of time sleeping, and showed no difference in stage shifts into the PS stage.

Note

Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada.

Netherlands

JID: 8004872; 0 (Neurotoxins); 14277-97-5 (domoic acid); 487-79-6 (Kainic Acid); 2009/06/09 [received]; 2009/07/10 [revised]; 2009/07/16 [accepted]; 2009/07/23 [aheadofprint]; ppublish

Source type: Electronic(1)

Language

  • English

Subjects

  • animals
  • Animals, Newborn
  • Time Factors
  • Electroencephalography
  • Sleep Disorders/chemically induced/physiopathology
  • Kainic Acid/analogs & derivatives/toxicity
  • Photoperiod
  • Rats, Sprague-Dawley
  • Male
  • Electrodes, Implanted
  • Electromyography
  • Neurotoxins/toxicity
  • Rats
  • Telemetry
  • Sleep Stages/drug effects/physiology
  • Brain/drug effects/physiopathology
  • Aging
  • Sleep, REM/drug effects/physiology
Page range
564-567
Host Title
Behavioural Brain Research
Host Abbreviated Title
Behav.Brain Res.
Volume
205
Issue
2
ISSN
1872-7549
0166-4328
DOI
https://doi.org/10.1016/j.bbr.2009.07.018

Department