Genre
- Journal Article
Alternation in the duration of consecutive cardiac action potentials (electrical alternans) may precipitate conduction block and the onset of arrhythmias. Consequently, suppression of alternans using properly timed premature stimuli may be antiarrhythmic. To determine the extent to which alternans control can be achieved in cardiac tissue, isolated canine Purkinje fibers were paced from one end using a feedback control method. Spatially uniform control of alternans was possible when alternans amplitude was small. However, control became attenuated spatially as alternans amplitude increased. The amplitude variation along the cable was well described by a theoretically expected standing wave profile that corresponds to the first quantized mode of the one-dimensional Helmholtz equation. These results confirm the wavelike nature of alternans and may have important implications for their control using electrical stimuli.
Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA.
United States
American Physical Society : Ridge, NY
Accession Number: 16605736. Language: English. Language Code: eng. Date Revised: 20100915. Date Created: 20060411. Date Completed: 20060525. Update Code: 20111122. Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.. Journal ID: 0401141. Publication Model: Print-Electronic. Cited Medium: Print. NLM ISO Abbr: Phys. Rev. Lett. PubMed Central ID: PMC1566349. Cites: Science. 1992 Aug 28;257(5074):1230-5. (PMID: 1519060). Cites: Phys Rev Lett. 2002 May 13;88(19):198102. (PMID: 12005667). Cites: J Appl Physiol. 1968 Aug;25(2):191-6. (PMID: 5666097). Cites: Nature. 1998 Mar 5;392(6671):78-82. (PMID: 9510250). Cites: Am J Physiol. 1998 Jul;275(1 Pt 2):H116-21. (PMID: 9688903). Cites: Circulation. 1999 Mar 16;99(10):1385-94. (PMID: 10077525). Cites: Ann Biomed Eng. 1999 Mar-Apr;27(2):180-6. (PMID: 10199694). Cites: J Cardiovasc Electrophysiol. 1999 Aug;10(8):1087-9. (PMID: 10466489). Cites: Proc Natl Acad Sci U S A. 2000 May 23;97(11):6061-6. (PMID: 10811880). Cites: Circulation. 2000 Oct 3;102(14):1664-70. (PMID: 11015345). Cites: Circ Res. 2000 Dec 8;87(12):1157-63. (PMID: 11110773). Cites: J Cardiovasc Electrophysiol. 2001 Feb;12(2):196-206. (PMID: 11232619). Cites: Proc Natl Acad Sci U S A. 2001 May 8;98(10):5827-32. (PMID: 11320216). Cites: Phys Rev Lett. 2001 Apr 16;86(16):3678-81. (PMID: 11328052). Cites: Circ Res. 2002 Feb 22;90(3):289-96. (PMID: 11861417). Cites: Phys Rev Lett. 2002 May 20;88(20):208101. (PMID: 12005608). Linking ISSN: 00319007. Subset: IM. Date of Electronic Publication: 2006 Mar 17; ID: 16605736
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Language
- English
Subjects
- animals
- Ventricular Fibrillation
- Purkinje Fibers/*metabolism
- Arrhythmias, Cardiac/diagnosis
- Arrhythmias, Cardiac/*pathology
- Heart Ventricles
- Dogs
- Electrophysiologic Techniques, Cardiac/*instrumentation
- Biophysics/*methods
- Electrocardiography
- Action Potentials
- Electrophysiologic Techniques, Cardiac/*methods
- Time Factors
- Heart Conduction System