Genre
- Journal Article
Theoretical studies have indicated that alternans (period-doubling instability) of action potential duration is associated with a restitution relation with a slope >or=1. However, recent experimental findings suggest that the slope of the restitution relation is not necessarily predictive of alternans. Here, we compared a return map memory model to action potential data from an ionic model and found that the memory model reproduced dynamics that could not be explained by a unidimensional restitution relation. Using linear stability analysis, we determined the onset of the alternans in the memory model and confirmed that the slope of the restitution curve was not predictive.
Department of Biomedical Sciences and Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.
United States
American Physical Society : Ridge, NY
Accession Number: 12225067. Language: English. Language Code: eng. Date Revised: 20071114. Date Created: 20020912. Date Completed: 20021105. Update Code: 20111122. Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.. Journal ID: 0401141. Publication Model: Print-Electronic. Cited Medium: Print. NLM ISO Abbr: Phys. Rev. Lett. Linking ISSN: 00319007. Subset: IM. Date of Electronic Publication: 2002 Sep 09; ID: 12225067
Source type: Electronic(1)
http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=12225067&site=eds-live&scope=site
Language
- English
Subjects
- Models, Cardiovascular*
- Heart/*physiology
- Action Potentials/physiology