Genre
- Journal Article
Contributors
Author: Drunen Littel-van, den Hurk
Author: Babiuk, L. A.
Author: Cox, G. J. M.
Author: Lewis, P. J.
Date Issued
1997
Abstract
A description of earlier work that demonstrated that cattle inoculated with a polynucleotide vaccine encoding bovine herpesvirus type 1 (BHV-1) gD are protected from challenge with virulent BHV-1. More recently, a mouse model has been used to identify the main parts of immunomodulation by polynucleotide vaccines. The model showed that use of a polynucleotide vaccine could avoid interference by passively transferred gD. This novel application will allow improvement and direction of appropriate immune responses in target species using polynucleotide vaccines.
Note
Lewis, P. J.: Veterinary Infectious Disease Organization, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3, Canada.
Language
- English
Subjects
- DNA viruses
- viral infections
- Alphaherpesvirinae
- immunity reactions
- bovine herpesviruses
- small mammals
- Immune response
- Host Resistance and Immunity (HH600)
- viruses
- animals
- carnivores
- recombinant vaccines
- eukaryotes
- viral diseases
- Canidae
- immunological reactions
- Dogs
- Varicellovirus
- disease models
- Mice
- Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
- Chordata
- rodents
- bovine herpesvirus 1
- Fissipeda
- Herpesviridae
- dog diseases
- Muridae
- dsDNA viruses
- mammals
- Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
- vertebrates
- Canis
Page range
861-864
Host Title
Vaccine
Host Abbreviated Title
Vaccine
Volume
15
Issue
8
ISSN
0264-410X