Genre
- Journal Article
This study was conducted to investigate the in vivo effect of a single intratracheal inoculation of Pasteurella haemolytica cytotoxin on the rat lung. Changes in the biochemical and cytological composition of bronchoalveolar lavage fluid were used to estimate the magnitude of pulmonary cell injury, inflammatory response, vascular permeability and functional status of pulmonary alveolar macrophages. Effect of treatment was compared with rats intratracheally inoculated with supernatants of Pasteurella multocida or with sterile physiological saline solution (vehicle). Results indicated that Pasteurella haemolytica supernatants were not significantly toxic for the lungs of rats.
LOPEZ A ; ANIMAL SCI WING, ALBERTA ENVIRON CENT, VEGREVILLE, ALBERTA T0B 4L0
PT: J; UT: BIOSIS:PREV198885048670
Source type: Electronic(1)
Language
- English
Subjects
- Pathology
- 36002, Medical and clinical microbiology - Bacteriology
- Respiratory System (Respiration)
- Infection
- Bacteria, Eubacteria, Microorganisms
- 16006, Respiratory system - Pathology
- physiology
- Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Rodents, Vertebrates
- 15008, Blood - Lymphatic tissue and reticuloendothelial system
- Toxicology
- 12508, Pathology - Inflammation and inflammatory disease
- Microorganisms
- Muridae [86375]
- 34508, Immunology - Immunopathology, tissue immunology
- 15010, Blood - Other body fluids
- Bacteria [05000]/Rodentia, Mammalia, Vertebrata, Chordata, Animalia
- 16001, Respiratory system - General and methods
- Blood and Lymphatics (Transport and Circulation)
- Immune System (Chemical Coordination and Homeostasis)
- 22501, Toxicology - General and methods