Genre
- Journal Article
Proanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H460 lung tumors, HT-29 colon and K562 leukemia cells at GI(50) values ranging from 20 to 80 mu g ml(-1). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) of one of these fractions found it to be composed of polyflavan-3-ols, which are primarily tetramers through heptamers of epicatechin containing one or two A-type linkages. Whole cranberry extract and the proanthocyanidin fractions were screened for effect on the expression of matrix metalloproteinases in DU 145 prostate carcinoma cells. The expression of MMP-2 and MMP-9 was inhibited in response to whole cranberry extract and to a lesser degree by the proanthocyanidin fractions. (c) 2005 Society of Chemical Industry.
Univ Massachusetts, Dept Chem & Biochem, N Dartmouth, MA 02747 USA. Univ Wisconsin, Dept Anim Sci, Madison, WI 53706 USA. Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo Ciencia & Tecnol, Lima, Peru. Univ Peruana Cayetano Heredia, Dept Mi(TRUNCATED)
Chichester
John Wiley & Sons, Ltd.
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Source type: Print
Language
- English
Subjects
- FRACTION
- LINES
- ADHERENCE
- FLIGHT MASS-SPECTROMETRY
- lung tumors
- identification
- matrix metalloproteinases
- proanthocyanidins
- FIMBRIATED ESCHERICHIA-COLI
- anticancer
- Human
- cranberry
- Food Science & Technology
- GRAPE SEEDS
- cytotoxicity
- Chemistry, Applied
- FIBROSARCOMA CELLS
- Agriculture, Multidisciplinary
- EXTRACT