Corcoran, A. M., and Robert I. Haines. “Kinetics of Interaction of the [Pd2Cl2(tppz)](2+) Cation With Guanine in Aqueous DMSO, and Solvatochromic Properties of the Complex in Aqueous DMSO Mixtures”. Inorganic Reaction Mechanisms, vol. 6, no. 2, 2006, pp. 83-89, https://doi.org/10.1515/irm.2006.6.2.83.

Genre

  • Journal Article
Contributors
Author: Corcoran, A. M.
Author: Haines, Robert I.
Date Issued
2006
Abstract

The binuclear complex bis-(chloropalladium(II))-tetrakis(2-pyridyl)pyrazine chloride, [Pd2Cl2(tppz)]Cl-2 has been synthesized and characterized. The complex shows solvatochromic behaviour in aqueous DMSO solvent mixtures. The kinetics of nucleophilic substitution of the complex by guanine is reported in 20% by volume aqueous DMSO. Only mono-substitution is observed, the dominant pathway being disscciative in nature. Temperature dependent studies give activation enthalpy and entropy values Delta H-double dagger=62.1 +/- 3.5 kJ mol(-1) and Delta S-double dagger=-67 +/- 10 J.K(-1)mol(-1). The reaction is completely suppressed in the presence of added chloride.

Note

Univ Prince Edward Isl, Dept Chem, Charlottetown, PE C1A 4P3, Canada.; Haines, RI, Univ Prince Edward Isl, Dept Chem, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada.; rhaines@upei.ca

PHILADELPHIA; 628 NORTH 2ND ST, PHILADELPHIA, PA 19123 USA

OLD CITY PUBLISHING INC

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Source type: Electronic(1)

Language

  • English

Subjects

  • OSMIUM(II)
  • sovatochromism
  • palladium(II)
  • tetrakis(2-pyridyl)-pyrazine
  • 2,3,5,6-TETRAKIS(2-PYRIDYL)PYRAZINE
  • cytotoxicity
  • drugs
  • Chemistry, Inorganic & Nuclear
  • guanine
  • DNA
  • SPECTROELECTROCHEMICAL PROPERTIES
  • Kinetics
Page range
83-89
Host Title
Inorganic Reaction Mechanisms
Host Abbreviated Title
Inorg.React.Mech.
Volume
6
Issue
2
ISSN
1028-6624
DOI
https://doi.org/10.1515/irm.2006.6.2.83

Department