Genre
- Journal Article
The reduction of the bicyclic G-factor endoperoxides G3 and G3Me was studied in N,N-dimethylformamide using cyclic voltammetry and convolution analysis. Electron transfer leads to irreversible cleavage of the O-O bond. Detailed analysis of the voltammetry curves reveals a non-linear dependence on the transfer coefficient indicating a mechanistic transition from a stepwise mechanism to one with more concerted character with increasing potential. By using quantum calculations to estimate the O-O bond dissociation energies, the experimental data was used to evaluate the standard reduction potentials and other pertinent thermochemical information.
Univ Toulouse 3, CNRS UMR 5068, Lab Synthese & Physicochim Mol Interet Biol, F-31062 Toulouse, France. ENSIACET, CNRS UMR 5085, Ctr Interuniv Rech & Ingn Mat, F-31077 Toulouse 4, France. Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canad(TRUNCATED)
WEINHEIM; PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
WILEY-V C H VERLAG GMBH
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Source type: Electronic(1)
Language
- English
Subjects
- electrochemistry
- TRIOXANES
- ANTIMALARIAL ACTIVITY
- HEME
- endoperoxide
- PEROXIDES
- BICYCLIC ENDOPEROXIDES
- ARTEMISININ
- Kinetics
- ALKYLATION
- MECHANISMS
- Chemistry, Multidisciplinary
- DIALKYL
- electron transfer
- radical ions
- G-FACTOR SERIES