Genre
- Journal Article
This review describes the mechanisms by which polyunsaturated fatty acids regulate the activity of the nuclear transcription factors, peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1, and it describes the role that the peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1 play in coordinating the regulation of lipid synthesis, lipid oxidation, and thermogenesis. Finally, the requirement for dietary polyunsaturated fatty acids, particularly n-3 fatty acids, is defined in terms of the effects polyunsaturated fatty acids exert on gene expression and the role that these effects play in overall energy balance.
Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712-1097, USA. pprice@mail.utexas.edu
ENGLAND
LR: 20061115; PUBM: Print; JID: 9010000; 0 (CCAAT-Enhancer-Binding Proteins); 0 (DNA-Binding Proteins); 0 (Dietary Fats, Unsaturated); 0 (Fatty Acids, Omega-3); 0 (Nuclear Proteins); 0 (Receptors, Cytoplasmic and Nuclear); 0 (SREBF1 protein, human); 0 (Sterol Regulatory Element Binding Protein 1); 0 (Transcription Factors); RF: 49; ppublish
Source type: Electronic(1)
Language
- English
Subjects
- Fatty Acids, Omega-3/pharmacology
- Sterol Regulatory Element Binding Protein 1
- Humans
- DNA-Binding Proteins/genetics
- Nuclear Proteins/genetics
- CCAAT-Enhancer-Binding Proteins
- Transcription Factors/genetics
- Gene Expression Regulation/drug effects
- Dietary Fats, Unsaturated/administration & dosage
- Receptors, Cytoplasmic and Nuclear/genetics