Genre
- Journal Article
Slow-reacting substance of anaphylaxis (SRS-A) is released immunologically from bovine lung in vitro. Various drugs known to protect calves and other animals during anaphylaxis were tested to investigate their modulation of the formation and release of SRS-A. The anti-inflammatory drugs, meclofenamate and aspirin, potentiated SRS-A release. Chlorphenesin and diethylcarbamazine citrate at high concentrations both inhibited SRS-A release. Two new anti-anaphylactic drugs, PR-D-92-EA and M&B 22,948, were particularly effective in inhibiting SRS-A release at low concentrations. The possible modes of actions of these drugs are discussed.
SWITZERLAND
LR: 20061115; PUBM: Print; JID: 0404561; 0 (Anti-Inflammatory Agents); 0 (Aza Compounds); 0 (Benzopyrans); 0 (Purinones); 0 (SRS-A); 104-29-0 (Chlorphenesin); 15826-37-6 (Cromolyn Sodium); 50-78-2 (Aspirin); 644-62-2 (Meclofenamic Acid); 90-89-1 (Diethylcarbamazine); 9014-72-6 (Polyphloretin Phosphate); 91-84-9 (Pyrilamine); ppublish
Source type: Electronic(1)
Language
- English
Subjects
- animals
- Aspirin/pharmacology
- Aza Compounds/pharmacology
- cattle
- Anti-Inflammatory Agents/pharmacology
- Cromolyn Sodium/pharmacology
- Benzopyrans/pharmacology
- Drug Synergism
- Lung/immunology
- Male
- Dose-Response Relationship, Drug
- Meclofenamic Acid/pharmacology
- Polyphloretin Phosphate/pharmacology
- Chlorphenesin/pharmacology
- Purinones/pharmacology
- Diethylcarbamazine/pharmacology
- Pyrilamine/pharmacology
- SRS-A/analysis/biosynthesis/metabolism/secretion