Genre
- Journal Article
Liver alterations were estimated morphometrically in male and female Sprague-Dawley rats that were fed PCB congener 77 (3,3',4,4'-tetrachlorobiphenyl) in concentrations of 0.01, 0.1, 1, 10 ppm or corn oil in diets for 13 weeks. A dose-dependent increase in the volume of smooth endoplasmic reticulum (SER) and an elevation in the volume of mitochondria following administration of the highest congener concentration (10 ppm) were estimated in the female rats. Hepatocytes of the male rats contained a significantly greater baseline volume of both SER and mitochondria compared to that in the females. A statistically significant (P < 0.05) change in the volumes of either SER or mitochondria in the PCB-fed males was not revealed. The authors concluded that the increase in mitochondrial volume was probably a necessary cellular adaptation to meet the heightened energy demands required by the SER to detoxify the PCB. The use of morphometric rather than a descriptive methodology allowed for a better determination of the hepatic alterations induced by PCB 77. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Univ Prince Edward Isl, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada. Dept Hlth & Welf, Hlth Protect Branch, Ctr Environm Hlth, Ottawa, ON K1A 0L2, Canada.; Singh, A, Univ Prince Edward Isl, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada.
CLARE; CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND
ELSEVIER SCI IRELAND LTD
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Source type: Electronic(1)
Language
- English
Subjects
- liver
- EXPOSURE
- VOLUME
- TCDD
- 3,3 ',4,4 '-tetrachlorobiphenyl
- Pharmacology & Pharmacy
- RAT
- SUBCHRONIC TOXICITY
- Toxicology
- ELECTRON-MICROSCOPE
- morphometry
- PCB 77
- INDUCTION
- 3,3',4,4'-TETRACHLOROBIPHENYL
- POLYCHLORINATED-BIPHENYLS