Genre
- Journal Article
2,4,4'-Trichlorobiphenyl or PCB congener 28 was given to Sprague-Dawley weanling rats and the experimental diets were prepared by mixing the congener in 4% corn oil. The congener was administered to animals placed in four groups, each comprising 10 males or females. The diets contained 0.05, 0.5, 5, or 50 ppm congener. The fifth or control group comprised animals that received diets mixed with corn oil. Thirteen weeks after commencement of dosing, animals were euthanized and liver specimens were harvested from the animals and prepared for electron microscopy and biochemical analyses. The hepatocyte architectural modifications included an augmentation of SER profiles and an elevation of peroxisome numbers in animals regardless of gender, and mitochondrial abnormalities in the females only. Mitochondrial aberrations consisted of abnormal shapes and cristae in atypical orientation. The alterations were revealed in animals of the 5- and 50-ppm groups and were more extensive in the females. Ethoxyresorufin-O-de-ethylase activity was significantly high in the animals of the 50-ppm group. The results suggest that the female rats were more sensitive than the males to congener 28, and the no observable adverse effect level (NOAEL) was believed to be 0.5 ppm for the congener.
HLTH PROTECT BRANCH,ENVIRONM HLTH DIRECTORATE,OTTAWA,ON,CANADA.; Singh, A, UNIV PRINCE EDWARD ISL,ATLANTIC VET COLL,550 UNIV AVE,CHARLOTTETOWN,PE C1A 4P3,CANADA.
BRISTOL; 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598
HEMISPHERE PUBL CORP
PT: J; CR: ALLEN JR, 1973, ARCH ENV CONTAM TOXI, V1, P265 BAUMANN M, 1983, ARCH ENVIRON CON TOX, V12, P509 CADOGAN JIG, 1962, J CHEM SOC, P4257 CHU I, 1994, FUND APPL TOXICOL, V22, P457 CHUI YC, 1985, TOXICOL APPL PHARM, V81, P287 COCHIN J, 1959, J PHARMACOL EXP THER, V125, P105 COLLINS WT, 1980, AM J PATHOL, V99, P125 CROSS PC, 1993, CELL TISSUE ULTRASTR, P26 DURHAM SK, 1989, TOXICOL PATHOL, V17, P536 DURHAM SK, 1989, TOXICOL PATHOL, V17, P782 ELANGBAM CS, 1991, B ENVIRON CONTAM TOX, V47, P321 FAWCETT DW, 1994, TXB HISTOLOGY, P668 FISHBEIN L, 1974, ANNU REV PHARMACOL, V14, P139 GHADIALLY FN, 1988, ULTRASTRUCT PATHOL, V1, P191 GILLETTE DM, 1987, FUND APPL TOXICOL, V8, P5 GRISHAM JW, 1994, AM J PATHOL, V144, P849 HANSELL MM, 1974, TOXICOL APPL PHARM, V28, P418 HARKNESS MR, 1993, SCIENCE, V259, P503 HARRIS C, 1984, ARCH ENVIRON CON TOX, V13, P715 HEINOMEN T, 1982, TOXICOLOGY, V22, P297 HINKLE PC, 1994, LIVER BIOL PATHOBIOL, P309 HINTON DE, 1978, VIRCHOWS ARCH B, V27, P279 JONSSON HT, 1981, ARCH ENV CONTAM TOXI, V10, P171 KASZA L, 1978, J ENVIRON PATHOL TOX, V1, P241 KIMBROUGH RD, 1972, ARCH ENVIRON HEALTH, V25, P354 LAZAROW PB, 1982, LIVER BIOL PATHOBIOL, P27 LIN FS, 1979, ARCH ENV CONTAM TOXI, V8, P321 LIPPINCOTTSCHWA.J, 1994, LIVER BIOL PATHOBIOL, P215 LUBET RA, 1985, MUTAT RES, V142, P127 MACLELLAN K, 1994, J SUBMICR CYTOL PATH, V26, P279 MANNELLA CA, 1993, J STRUCT BIOL, V108, P227 NISHIHARA Y, 1985, BRIT J IND MED, V42, P128 NISHIZUMI M, 1970, ARCH ENVIRON HEALTH, V21, P620 ROSS MH, 1989, HISTOLOGY TEXT ATLAS, P17 SAFE SH, 1994, CRIT REV TOXICOL, V24, P87 SATO T, 1968, J ELECTRON MICROSC, V17, P158 SCHECTER A, 1984, BANBURY REPORT, V18, P177 SCHECTER A, 1985, ENVIRON HEALTH PERSP, V60, P241 SCHENKMAN JB, 1967, MOL PHARMACOL, V3, P113 SINGH A, 1981, PATHOLOGY, V13, P487 STOTZ IJ, 1978, B ENVIRON CONTAM TOX, V19, P319 TONER PG, 1992, OXFORD TXB PATHOLOGY, V1, P173 WEISS L, 1988, CELL TISSUE BIOL TXB, P1; NR: 43; TC: 7; J9: ULTRASTRUCT PATHOL; PG: 10; GA: UL536
Source type: Electronic(1)
Language
- English
Subjects
- PCBS
- 2,4,4'-trichlorobiphenyl
- EXPOSURE
- Pathology
- Biochemistry
- electron microscopy
- RAT
- LIGHT
- Microscopy
- PCB congener 28
- POLYCHLORINATED-BIPHENYLS