Is the state of leucocyte adhesivensess/aggregation an immune marker of stress in the olfactory bulbectomized rat?

Determined leucocyte adhesiveness/aggregation (LAA) during stress in 44 rats following sham operation or olfactory bulbectomy. The effects of chronic treatment with the antidepressant desipramine and calf thymopeptides on the LAA state and differential white cell count were also assessed. In the olfactory bulbectomized Ss, LAA percentages and ratios were significantly increased compared with sham-operated Ss. In the white cell count, the percentage of neutrophils was markedly increased while the percentage of lymphocytes was decreased. Chronic desipramine treatment had no effect on lesioned changes in the LAA and the proportion of white cells. However, thymopeptides significantly reduced LAA percentage and normalized the lymphocyte and neutrophil count in the bulbectomized Ss.